Mass Transport Modeling of Tumor Contrast Agent Enhancement
Award year: 2007-2008
We seek to improve diagnostic tumor physiology parameter estimates obtained from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) by developing a mass transport theory model for tumor contrast agent extravasation that incorporates contrast agent-water exchange effects and show its relation to multi-compartment models. The model will relate mathematical terms for convection and diffusion of both proton signal and contrast enhancement between image volume pixels, "voxels", to improve mapping of tumor contrast agent extravasation. For clinical application this complex mathematical modeling will require rapid computation, thus requiring innovative hardware/software solutions for practical implementation in radiological screening and diagnosis of malignancy.
Aref will work with NCSA's Volodymyr Kindratenko, a researcher in the center's Innovative Systems Laboratory